Zoloft (Sertraline)

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Generic Name: Sertraline
Dosage: 25mg, 50mg, 100mg
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Generic Zoloft is widely known as a remedy for treatment of initial or chronic episodes of depression. This antidepressant has sertraline as its active material. The latter does not cause drug dependence or body weight increase (after long-term taking).

The active material has little influence on the reuptake of norepinephrine and dopamine. When taken in therapeutic doses, it blocks 5-hydroxytryptamine reuptake in human platelets. It has no stimulatory, sedative or anticholinergic effect. Thanks to the selective inhibition of thrombotonin, this material does not intensify the adrenergic activity.

When doctors prescribe sertraline

There are some illnesses that are often treated with this medication

  • Panic disorders (including the cases with agoraphobia)
  • Obsessive-compulsive disorders
  • Posttraumatic depressive disorders
  • Depressions with manic states
  • Social phobia
  • Depressions with apprehensive feelings

Generic Zoloft may be also used as a preparation for recurrence prophylaxis.

Pharmacological action

The inhibition of 5-hydroxytryptamine reuptake increases the serotonergic transmission, which results in the consequent inhibition of adrenoceptive activity in the locus coeruleus. Zoloft also inhibits the stimulation of serotonin neurons in and around the midline of myelencephalon, which leads to the initial increase in locus coeruleus activity with subsequent decrease in the activity of postsynaptic beta-adrenergic receptors and presynaptic alpha-2 adrenergic receptors.

This pharmaceutical does not cause drug dependency. There is no awareness-inducing, sedative, anticholinergic, and cardiotoxic effect; psychomotor activity is not changed. Sertraline also does not increase the activity of sympathetic nervous system due to the selective inhibition of serotonin reuptake.

The initial effect is developing for 7 days, the full one requires 2-4 weeks.

Adverse reactions to generic Zoloft

Doctors and pharmacists list the following side reactions as common:

  1. Xerostomia
  2. Bleeding (including nasal hemorrhage)
  3. Allergic reactions
  4. Palpitation
  5. Anorexia

There are also illnesses that happen less frequently:

  • Appetite increase (may be as a consequence of eliminated depression)
  • Sickness
  • Emesis
  • Unstable stool
  • Diarrhea
  • Abdominal convulsions
  • Tympanism
  • Body weight loss
  • Headache
  • Giddiness
  • Pervigilium
  • Somnolence
  • Tremor
  • Convulsions
  • Akathisia
  • Paresthesia
  • Symptoms of depression
  • Hallucinations
  • Aggressiveness
  • Dermahemia

The traditional methods of treatment include:

  1. Ensuring the patency of airways (oxygenation and pulmonary ventilation)
  2. Gastric lavage
  3. Emetic drugs prescription (sorbitol and activated charcoal)
  4. Control of heart and liver functions

The following methods are ineffective: artificial diuresis, dialysis, hemoperfusion, and replacement blood transfusion.

Can I find Zoloft without prescription somewhere?

As a rule, this medication is distributed according to the prescriptions. Nevertheless, it is possible to find available drugs without prescription. In any event, you need to remember that it may be dangerous to take the medicine on your own. Do not risk your health ― come to consult your doctor at first.

What should I do in case of overdose?

First, you need to know that severe symptoms of an overdose with this drug are not detected. However, taking the medication simultaneously with other pharmaceuticals or alcohol may cause severe poisoning right up to coma or fatal outcome.

If you are concerned about possible overdose, you need to seek for emergency medical aid as soon as possible.

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