Tramadol (Ultram)

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Generic Name: tramadol (TRAM a dol)
Dosage: 50mg, 100mg
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Generic Tramadol is a synthetic opioid analgesic that is notable for its evident central action and influence on spinal marrow: it facilitates the opening of potassic and calcic channels, brings on membrane hyperpolarization, and inhibits the transmission of pain impulses. It is also responsible for the inhibition of catecholamines, stabilizing its content in central nervous system.

It is also known by its generic name, which is Ultram. This active material activates opioid receptors (mu-, delta-, kappa-) in presynaptic and postsynaptic membranes of nociceptive system afferent fiber in brain and gastrointestinal tract.

Pharmacological action

Ultram is characterized by its impressive analgetic (anesthetic) activity. It is notable for quick and prolonged effect, though the medicine is inferior to morphine in terms of activity when taking the same doses. Subsequently, the medication is taken in bigger doses.

After perioral administration, the medication quickly and almost completely dissolves in gastrointestinal tract. Therapeutic concentration is reached in about 2 hours and lasts for 12 hours.

Patients aged 75 and more experience the increase of maximal drug concentration in blood, while the half-life becomes prolonged. Thus, the dosage should be decreased.

Safety precautions

Before the beginning of your course of treatment with Tramadol, tell your doctor whether you have an allergic reaction to this drug or any other opiates. Be sure to look through the list of its components ― you can ask your pharmacist for it. Consult your physician in case you take any other medications, vitamins, or food additives without prescription.

In case you suffer any of these illnesses ― come see a doctor before starting the treatment:

  1. Fainting sickness
  2. Opioid addiction
  3. Impairment of consciousness of different genesis
  4. Intracranial pressure
  5. Craniocerebral trauma
  6. Abdominal emergencies
  7. Liver or renal dysfunction

The medicine may be prescribed for pregnant women during the second and third trimesters of pregnancy under the strict surveillance. It happens when the benefits of treatment exceed the risks.

What adverse reactions to Tramadol may happen?

There is a list of common side reactions:

  • Constipation
  • Diarrhea
  • Dry mouth
  • Giddiness
  • Menstrual irregularities
  • Headache
  • Inertia

There is also a possibility of some allergic reactions:

  1. Nettle rush
  2. Pruritus
  3. Exanthema
  4. Bullous eruption

Here are some other possible side effects:

  • Dyspnea
  • Drug dependence (after long-term taking)
  • Abstinence syndrome (after a sudden cessation of taking)

How does Tramadol interact with other medicinal agents?

It is not recommended to use ultram with monoamine oxidase inhibitors. The simultaneous use with the preparations that affect central nervous system (anesthetic agents, antidepressants, neuroleptics, sedative drugs, anxiolytics, or soporifics) or alcohol drinks, the synergic effect is possible. It becomes evident due to the increased sedative effect or intensified anodyne effect.

When taking simultaneously with carbamazepine, the metabolism is boosted, which requires the increased dose of preparation.

The synchronous use of this drug with serotonin reuptake inhibitors, tricyclic antidepressant, or neuroleptics, may increase the risk of convulsions onset.

Can I find generic Tramadol without prescription? Is it safe?

Every doctor will recommend you to take this medicine only if it has been prescribed for you. Even though it is possible to find the drug without it, you need to understand the potential danger of such usage. It is always better to consult a physician or pharmacist before taking these pharmaceuticals.

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