Meridia (Sibutramine)

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Generic Name: Sibutramine (si BUE tra meen)
Dosage: 10mg, 15mg
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Generic Meridia is a weight reducing aid, which influences the brain center that is responsible for appetite control. As a result, it becomes easier to maintain a diet.

The active material of this pharmaceutical is sibutramine. Being in human organism, this material penetrates into the brain with the bloodstream and causes the reduction of appetite.

A patient does not feel hungry because his or her nutritional requirement is reduced by 30%. Experiments have shown that Meridia is highly efficient and has a long-term effect. The preparation has been put to the test with help of 20.000 volunteers from all over the world. Experts have found no severe adverse effects.

Manufacturers claim that this pharmaceutical has additional merits:

  1. Patients with excess weight experience the normalization of fatty acids and sugar in blood while taking the medicine
  2. It improves the quality of hemoglobin in blood
  3. The food is digested better

Generic Meridia is usually not available without prescription. Doctors highly recommend using the drug only in case you have the prescription. Remember that self-treatment may be dangerous for your health ― it is always better to consult a doctor before taking such medicine.

Pharmacological action

Sibutramine is metabolized in organism with the formation of pharmacologically active materials. Its metabolites inhibit the specific monoamines (serotonin and noradrenaline in particular), which leads to the enlargement of its content in synapses and increased activity of central adrenergic and 5-ht serotonin receptors. Such influence facilitates higher satiety, while reducing the nutritional requirement and increasing thermal production.

When it can be prescribed

Generic Meridia is used as a remedy for maintenance therapy among patients who suffer alimentary obesity. Particularly, this medication is often prescribed in case of such indices:

  • Body weight index is higher than 30 kg/m2
  • Body weight index is higher than 27 kg/m2 and there are additional risk factors, conditioned by overweight

The latter includes lipid metabolism abnormalities and type 2 pancreatic diabetes.

Which adverse reactions sibutramine may cause?

Patients usually have a good tolerance of this active material. The development of side effects is most likely to happen in the first month of therapy. The majority of adverse reactions are ill-defined and pass by their own without the cessation of treatment or specific therapy.

Particularly, patients may suffer adverse effects on the central nervous system side, such as:

  • Giddiness
  • Paresthesia
  • Somnipathy
  • Anxiety
  • Headache

There is also a possibility of emotional instability, depression, somnolence, convulsions, nervousness, and uneasiness.

What is contraindicated to Meridia?

This preparation is not prescribed for patients that are intolerant to the active material or additional components of the drug, including people who have inherited lactose intolerance.

The preparation should not be used in therapy for patients who suffer hyperthyroidism, evident renal and liver dysfunction, pheochromocytoma, angle-closure glaucoma, and non-malignant prostatic hypertrophy with urinary retention.


When taking big doses of the drug, patients may suffer the adverse reactions. It could be tachycardia, giddiness, arterial hypertension, and headache.

In case of overdose there are indications of gastric lavage and prescription of enterosorbents during the 60 minutes after taking an increased dose. After that, it is recommended to observe the sick pending 24 hours.

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